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This page/column contains information which may be of interest to consumers. The information is based on articles which appear in Australian Prescriber. As Australian Prescriber is written for health professionals, you should discuss any issues raised by this page/column with your doctor or pharmacist. They will be able to give a more detailed answer to your questions by reading the main article.

Australian Prescriber is unable to comment on individual cases or give second opinions.

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Australian Prescriber Vol. 24 No. 5 2001

Alternatives to cisapride (Prepulsid)

Cisapride was a drug that was used to treat several types of stomach problem. It will not be used so much in future because of safety concerns. In some patients cisapride can cause an abnormal heart rate; this can be fatal.

In Australia the Pharmaceutical Benefits Scheme has restricted cisapride to only one condition (when the stomach fails to contract and empty). Cisapride can only be prescribed after the patient has seen a specialist.

Most people taking cisapride for other conditions will have to stop. These conditions will usually respond to a different medicine.

If you continue to take cisapride avoid grapefruit juice as it can increase side effects.